• Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid 

  Mbah, C.J.; Okorie, H.N. (2011)

  A spectrophotometric study of chlorpropamide is described. The method is based on the charge-transfer complexation between chlorpropamide (the n-electron donor) with chloranilic acid (the π-acceptor) to form a violet ...
• Formulation Development of Theophylline in Coated Polymeric Pellets for Controlled Oral Drug Delivery 

  Obitte, Nicholas, C.; Okorie, Abali, Sunday (2015)

  This work is aimed at producing theophylline pellets for controlled oral drug delivery. Eight batches of theophylline pellets were prepared containing varying combinations (2.5 – 10% w/w) of sodium carboxymethyl cellulose, ...
• Kinetics of Decomposition of Irbesartan in Aqueous Solutions Determined by High Performance Liquid Chromatography 

  Mbah, C.J. (2004)

  The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the ...
• Physical and Mechanical Effects of Starch-Gelatin Binary Binder Mixtures on Sodium Salicylate Tablets 

  Agubata, Chukwuma O.; Onunkwo, Godswill C.; Ugwu, Calister, E.; Chime, Salome, A. (2012)

  Starch- gelatin binary binder mixtures were applied in the formulation of sodium salicylate tablets. Locally developed cassava starch (tapioca starch) was used as a co-binder with gelatin. Wet granulation method was used ...
• Physicochemical Properties of Valsartan and the Effect of Ethyl Alcohol, Propylene Glycol and PH on its Solubility 

  Mbah, C.J. (2005)

  The aqueous solubility and partition coefficient of valsartan were determined at room temperature. The effect of ethyl alcohol, propylene glycol and pH on its solubility was also investigated. It was found that both solvents ...
• Solid Self Emulsifying Drug Delivery System Based on a Homolipid and Vegetable Oil: A Potential Vehicle for the Delivery of Indomethacin a Disadvantaged Drug 

  Obitte, Nicholas, C.; Ofokansi, Kenneth C.; Chime, Salome, A.; Idike, Ebele (2013)

  Background: The successful utility of some biocompatible natural excipients may be more advantageous over their synthetic counterparts in drug formulations. Indomethacin is a potent non steroidal anti inflammatory drug ...
• Comparative Adsorption of Spiramycin on Veegum®, Activated Charcoal and Garcinia kola Heckel (Guttiferea) Seed 

  Okonkwo, Chukwudi, T.; Nzekwe, Ifeanyi T.; Okorie, Ogbonna; Okonkwo, Tochukwu J.; Agubata, Chukwuma O.; Mbah, Chukwuemeka C.; Esimone, Charles O (2015)

  Purpose: To investigate the adsorptive interaction of Garcinia kola with spiramycin, since the kola is widely chewed as a tonic and spiramycin attains high concentrations in saliva. Methods: Spiramycin solutions of different ...
• Formulation and Evaluation of the Bioadhesive Properties of Drug Delivery System Based on PEGylated Mucin Matrices 

  Momohmumuni, Audu; Adikwu, Michael Umale; Ibezim, Emmanuel Chinedum (2010)

  Objective: To formulate and evaluate the application of PEGylated mucin in oral bioadhesive drug (OBD) delivery system. Methods: The bioadhesive strength of different formulation ratios of polyethylene glycol (PEG) and ...
• Formulation, Characterization and Ex-vivo Permeation Studies on Gentamicin-Loaded Transdermal Patches Based on PURASORB® Polymers 

  Nnamani, Petra Obioma; Kenechukwu, Franklin Chimaobi; Dibua, Esther Uju; Ogbonna, Celestine Chidi; Momoh, Mumuni Abdul; Olisemeka, Augustina Uche; Agubata, Chukwuma Obumneme; Attama, Anthony Amaechi (2013)

  Topical administration of gentamicin, an aminoglycoside antibiotic commonly used for treatment of bacterial infections, is limited by toxicity and membrane impermeability. The purpose of this study was to develop an ...
• In-vitro Evaluation of Shea Butter-Based Nystatin Microparticles 

  Nwuke, H.C.; Nzekwe, I.T.; Agubata, C.O.; Ofokansi, K.C.; Okorie, O.; Okore, V.C.; Esimone, C.O. (2015)

  Nystatin, an antifungal drug for mucosal infections has a large dosing frequency and is rapidly inactivated by acids. In order to increase drug stability and reduce dosing frequency and reduce dosing frequency and gastric ...
• QSAR on Aryl-Piperazine Derivatives with Activity on Malaria 

  Ibezim, Emmanuel; Duchowicz, Pablo R.; Oritz, Erlinda V.; Castro, Edurado A. (2012)

  In this work we offer linear regression models on a set of aryl-piperazine derivatives that are obtained by exploring a pool containing 1497 Dragon molecular descriptors, in order to establish the best relationships linking ...
• Seasonal Variation for the Antidiabetic Activity of Loranthus micranthus Methanol Extract 

  Osadebe, Patience Ogoamaka; Omeje, Edwin Ogechukwu; Uzor, Philip Felix; David, Ernest kenechukwu; Obiorah, Damian Chiedozie (2010)

  Objective: To determine the season in which the Eastern Nigeria Mistletoe, Loranthus micranthus, parasitic on Persea americana possesses optimum antidiabetic activity and to determine the seasonal variation in the ...
• Synthesis of Silver Nanoparticles by Sodium Borohydride Reduction Method: Optimization of Conditions for High Anti-Staphylococcal Activity 

  Nzekwe, Ifeanyi T.; Agubata, Chukwuma O.; Umeyor, Chukwuebuka E.; Okoye, Ifeanyi T.; Ogwueleka, Chidalu B. (2016)

  Aim: The aim of this research was to optimize the reaction conditions for the production of silver nanoparticles sufficiently bioactive for incorporation into pharmaceutical gels. Methods: Silver nanoparticles were prepared ...
• Evaluation of the Acute and Sub Acute Toxicity of Annona senegalensis root bark extracts 

  Okoye, Theophine C; Akah, Peter A.; Ezike, Adaobi C.; Okoye, Maureen O.; Onyeto, Collins A; Ndukwu, Frankline; Ohaegbulam, Ejike; Ikele, Lovelyne (2012)

  Objective: To investigate the safety profile of Annona senegalensis (A. senegalensis). Methods: Dried powdered root-bark of A. senegalensis was prepared by Sohxlet extraction using methanol-methylene chloride (1:1) solution ...
• Ethnobiological Study of Traditional Medicine Practices for the Treatment of Chronic Leg Ulcer in South Eastern Nigeria 

  Nwafor, Felix I.; Tchimene, Michel K.; Onyekere, Peculiar F.; Nweze, Nkechinyere O.; Orabueze, Celestina I. (2018)

  A comprehensive survey was carried out to document plants and non-plant materials used in traditional medicine practices for the treatment of chronic leg ulceration in 13 randomly selected Local Government Areas in Anambra ...
• Antiulcer Activity of Methanolic Extract and Fractions of Picralima nitida seeds (Apocynacaea) in Rats 

  Okonta, Jagbefume Mathew; Adibe, Maxwell Ogochukwu; Ubaka, Chukwuemeka Micheal (2011)

  Objective: To investigate the antisecrectory activities of the methanol extract, chloroform fraction and methanol fraction of Picralima nitida seeds. Methods: The methanol extract of Picralima nitida seeds was fractionated ...
• Anti-ulcer Activity of Combretum obanense Stem Bark (Bak. F) Hutch and Dalz 

  Tchimene, M.K.; Obonga, W.; Ugwoke, C.E.C.; Nwafor, F.; Iwu, M.M. (2015)

  The study was designed to investigate the antiulcer activity of methanol/methylene chloride (1:1) of Combretum obanense using different models of gastric ulceration in rats. Gastric ulcers were induced by oral administration ...
• Anti-Plasmodial and Antioxidant Activities of Methanol Extract of the Fresh Leaf of Lophira lanceolata (Ochnaceae) 

  Onyeto, Collins Azubuike; Akah, Peter Achunike; Nworu, Chukwuemeka Sylvester; Okoye, Theophine Chinwuba; Okorie, Nkemakolam Austine; Mbaoji, Florence Nwakaego; Nwabunike, Amarachukwu Ifeoma; Okumah, Nelson; Okpara, Obinna (2014)

  This study was aimed at investigating the anti-plasmodial and antioxidant activities of the extract of the leaf of Lophira lanceolata, a traditional medicine recipe. The methanol extract (ME) obtained by 72 h cold maceration ...
• Antimalarial Activity of Ageratum conyzoides in Combination with Chloroquine and Artesunate 

  Ukwe, Chinwe V.; Ekwunife, Obinna I.; Ekpueke, Ebele A.; Ubaka, Chukwuemeka M. (2010)

  Objective: To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides ( A. conyzoides) in combination with chloroquine and artesunate, respectively against Plasmodium berghei infection ...
• Application of Abelmoschus Esculentus in Solid Dosage Formulation 1: Use as a Binder For a Poorly Water Soluble Drug 

  Ofoefule, S.I.; Chukwu, A.; Anyakoha, N.; Ebebe, I.M. (2001)

  A gum Extracts from the pods os Abelmoschus esculentus (Ae) was evaluated as granulating agent for sulphaguanidine granules and tablets. The gum was employed at concentrations of 0,2,4 and 6%(w/w) and granules and tablets ...

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