Abstract:
The efficacy of increasing dieses (3.5,70,14 and 21 mg/kg)of samornil;a diminanzene based trypanocide was investigated in Albion rats experimentally infected with trypanonsoma brucei.Thirty albino rats were used for the study.The rats were divided into six groups of five rats each.Groups III, IV, V, VI were infected with 1.0 x 10 trypanosomes intreperitioneally and were later treated at day 9 post infection with3.5, 7.0, 14, and 21 mg/kg of samorenil*respectively.Group one serves as negative control (uninfected untreated)while group II serves as positive (infected untreated).The parameters monitored for the therapeutic assessment of the increasing doses of samoreenil*were parasitaemia,rectal temperature,packed cell vlume(PCV),and body weight.Following treatment,there was complete aparasitaemia at 96 hours posttreatment in all theinfected treated rats.There was also an improvement in the clinical condiction of the experimental rats.Four rates in positive control(groups II) (infected untreated)died by day 35 post infection and the remaining one died at the day 70 post infection.Relapse infection however occurred at day 35,49 and 63-post treatment in groups treated with3.5, 7.0 and 14mg/kg respectively.There was no relapse infection in the group treated with 21mg/kg.It was thus concluded that there may be merit in using higher doses of samorenil*in treatment of trypanosomosis.The possible toxic effect of these higher doses however needs to be further investigated to ascertain the safety or otherwise of the higher doses used.
