Application of Abelmoschus Esculentus in Solid Dosage Formulation 1: Use as a Binder For a Poorly Water Soluble Drug

Abstract

A gum Extracts from the pods os Abelmoschus esculentus (Ae) was evaluated as granulating agent for sulphaguanidine granules and tablets. The gum was employed at concentrations of 0,2,4 and 6%(w/w) and granules and tablets were prepared by the weight granlation method. Properties of granules and tablets evaluated as a function of the gum concentration include: loose densities, flow rate and angles of repose, hardness and friability, disintergration timeand dissolution profiles. Granules prepared with Ae possessed good flow characteristics and the polymer exhibited higher binding capacity in sulphaguanidine tablets than maize starch and the gelatin at eqivalent concentrations. The gum could be employed as a granulating agent in normal release sulphaguaanidine tablets at concentration levels of 2 and 4%(w/w). Beyond these concentrations, sulphaguanidine tablets with relatively prolonged released profile was obtained.