Abstract:
In many parts of Nigeria, fresh palm wine obtained from the specie, Elaisguineensis has long been used as a lactogenic by women who just delivered a baby. The aim of this study was to, by means of in-vitro methods, evaluate the effect of palm wine on the release properties of Amoxicillin (a commonly used antibiotic in lactating women) immediate release capsules and metformin sustained release(SR) tablets (a commonly used antidiabetic in lactating women). The test was carried out using the Magnetic stirrer apparatus and methods from (USP 2009). Simulated gastric fluid(SGF) of PH=1.2 and Phosphate buffer(Ph.B) of PH6.8 were used to simulate the gastrointestinal environment. Each drug was simultaneously tested in each of SGF and Ph.B dissolution media containing, no palm wine, fresh, and 24-hour old palm wine respectively . The dissolution profile obtained for each drug in each of the media was compared and analysed using a paired sample t-test. It was concluded that palm wine causes statistically significant reduction in the release of metformin from SR tablet formulations. Palm wine, however has no significant effect on release profile of Amoxicillin from IR tablet formulations.
